Teaser from my upcoming submission – Changes of cognitive-affective neural processing following active-controlled mindfulness intervention

by Neuroconscience

As I’ve been dreadfully quiet in the weeks leading up to the submission of my first fMRI paper, I thought I’d give my readers a little tidbit teaser of my (hopefully) forthcoming article. We’re within days of submission and I’ve got high hopes for a positive review. Here is the abstract:

Mindfulness meditation is a set of attention-based, regulatory and self-inquiry training regimes. Although the impact of mindfulness meditation training (MT) on self-regulation is well established, the neural mechanisms supporting such plasticity are poorly understood. MT is thought to act on attention through bottom-up salience and top-down control mechanisms, but until now conflicting evidence from behavioral and neural measures has made it difficult to distinguish the role of these mechanisms. To resolve this question we conducted a fully randomized 6-week longitudinal trial of MT, explicitly controlling for cognitive and treatment effects. We measured behavioral metacognition and whole-brain BOLD signals during an affective Stroop task before and after intervention. Although both groups improved significantly on a response-inhibition task, only the MT group showed reduced affective Stroop conflict. Moreover, the MT group showed greater dorsolateral prefrontal cortex (DLPFC) responses during executive processing, indicating increased recruitment of top-down mechanisms to resolve conflict. Individual differences in MT adherence predicted improvements in response-inhibition and increased recruitment of dorsal anterior cingulate cortex (dACC), medial prefrontal cortex (mPFC), and right anterior insula during negative valence processing, suggesting that rigorous mindfulness practice precedes alterations of bottom-up processes.

And a teaser figure:

Image

Figure 5, Greater levels of meditation practice predict increased dorsolateral prefrontal, right anterior insula, and medial-prefrontal BOLD recruitment during negative > neutral trials. pFWE < 0.05 corrected on cluster level, voxel selection threshold p = 0.001.

Things are fantastic, especially since I’ve moved to London. The ICN is a great place for cognitive neuroscience and I’m learning and doing more than I ever have before. While I prepare this paper, I am simultaneously finishing up a longitudinal VBM analysis of the same data, and beginning to script an eventual 60 subject affective-stroop Dynamic Causal Modeling connectivity study. Everyone here is insanely talented and there is hardly a day that goes by when there isn’t some interesting discussion, a fascinating talk, or an exciting collaboration to be had.

disclaimer: these findings have NOT been peer reviewed and as such should not be believed nor reported as science! They’re just pretty pictures for now.